Conventional radiation therapy (CRT) has traditionally been used in patients with residual or recurrent secreting and nonfunctioning pituitary adenomas who have failed prior medical management and/or surgery, resulting in a variable long-term tumor control of 87–95 % at 10 years [1–4], and normalization of elevated plasma levels of growth hormone (GH) and adrenocorticotropic hormone (ACTH) in up to 55 %, and 78 % of patients, respectively [5–8]. This evidence concerns the gene POMC and pituitary gland adenoma.