In RA synovitis, not only T cells, but also synovial macrophages and fibroblasts over-express IL-7Rα, thereby making IL-7Rα the transcript most differentially expressed between RA and other inflammatory joint conditions such as osteoarthritis, systemic lupus erythematosus, psoriatic arthritis and gout [6–8]. The gene discussed is IL7R; the disease is osteoarthritis.