ACKR3 and cancer: In addition, our results also depicted the differential expression of cytokine receptors (il2ra, il12rb2, il21r and il22ra), chemokine receptors (ccr3, xrc1 and cxcr7) and tumor necrosis factor receptors (tnfrsf1b, 9, 11a and 25) supporting further modulation of cross-talk between cancer and their microenvironment in ECM dependent manner, which cannot be established in 2D cultures.