Shearer etal. (2014) proposed a threshold of 0.0005 for considering avariant as pathogenic in an autosomal dominant fashion, in the general population.However, the allelic frequency was 0.004 (6/1476 alleles) in our study, suggesting apossible association with deafness. Further studies are needed to elucidate thepathogenicity of GJB3 variant c.538C > T. The gene discussed is GJB3; the disease is deafness.