The reduced virulence of the ISW2 null mutant DRL6 in a mouse model of disseminated candidiasis was associated at day 2 PI with decreased up-regulation of IL-6, TNF-α, MIP1-α, and IL-10, cytokines and chemokines that are known to play a role in innate host defense against Candida in vivo [58, 74, 75]. The gene discussed is TNF; the disease is disseminated candidiasis.