Here, in the Adaptive Study of IL-2 Dose on Regulatory T Cells in Type 1 Diabetes (DILT1D), the effects of single-dose aldesleukin were investigated by observing multiple biomarkers before treatment (baseline), at 90 min after drug administration, daily for 4 d, and then intermittently for 9 wk. Here, IL2 is linked to type 1 diabetes mellitus.