Others have found 745T protective in tuberculosis patient studies and associated with lower NF-κB signaling, decreased production of IL-6 in whole blood stimulated with TLR2/6 ligand PAM2 and Mtb lysate [73], and increased production of IFN-γ in whole blood stimulated with Bacillus Calmette-Guérin as well as PBMCs stimulated with TLR1/6 lipopeptide ligands [74]. This evidence concerns the gene NFKB1 and tuberculosis.