To investigate the influence of dasatinib on signal transduction pathways, we investigated the changes in JAK‐STAT, mitogen‐activated protein kinase (MAPK), and AKT in cytotoxic lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), before and after dasatinib treatment in chronic myeloid leukemia patients. This evidence concerns the gene SOAT1 and chronic myelogenous leukemia, BCR-ABL1 positive.