reported that combination of all‐transretinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) in melanoma cell lines upregulated the expression level of IL‐1β, IL‐6, IFN‐β, CXCL10, CXCL9, CXCL8, and CXCL1 more than treatments with either ATRA or polyI:C separately, which was mediated by toll‐like receptor 3 and MDA5. The gene discussed is CXCL9; the disease is melanoma.