CXCL9/CXCR3‐A could promote tumor migration and invasion via PI3K 33, MAPK 74, pathways and so on, but CXCL9/CXCR3‐B could inhibit endothelial cells proliferation 115 and tumor angiogenesis 36, which might be mediated by VEGF/VEGFR2 (KDR) and its downstream phospholipase Cγ, p‐JNK, and p‐ERK 24. This evidence concerns the gene MAPK8 and neoplasm.