CD4 and neoplasm: In addition, other studies have also demonstrated that Egr‐1 deficiency 22, IL‐7 39, CCL21 40, and myeloid‐derived suppressor cells depletion 41 reduced tumor burden by upregulating CXCL9 and CXCL10 expression, which played an anti‐angiogenic role and attracted tumor macrophages, CD4 and CD8+ T lymphocytes, and NK cells.