Furthermore, a recent study found that S. Typhi could induce transformation in murine gallbladder organoids and fibroblasts, although only in the presence of predisposing mutations (i.e., inactivated TP53 mutations and c‐MYC amplification), and that by causing such mutations in gallbladder tissue, S. Typhi may have stable transformative effects that remain even after the infection is eradicated 61. The gene discussed is TP53; the disease is infection.