EGFR and neoplasm: To test whether H1975 and H1993 tumors were resistant to erlotinib and to demonstrate that animal treatment with WZ4002 or crizotinib could overcome T790M-mediated resistance or MET amplification, respectively, we determined the levels of cyclin D1, one of the terminal mediators of EGFR signaling pathways, in untreated and treated tumor-bearing animals (Fig. 2).