In our previous studies, we showed that the inhibition of EGFR signaling in NSCLC cells inhibits aerobic glycolysis and restores oxidative phosphorylation through the concerted downregulation of hexokinase II (HKII) and pyruvate kinase M2 phosphorylated at Tyr105 (p-PKM2 Tyr105) and upregulation of mitochondrial complexes (OXPHOS) [16]. The gene discussed is PKM; the disease is non-small cell lung carcinoma.