EGFR and non-small cell lung carcinoma: In sensitive NSCLC cells, the rapid reduction of 18F-FDG uptake in response to EGFR TKIs was mainly correlated with the inhibition of the PI3K/AKT pathway, reduction of hexokinase activity, and downregulation of glucose transporters [15] that largely preceded any measurable changes in the percentage of cells undergoing apoptosis.