In particular, the selective inhibition of the AKT pathway in NSCLC cells resulted in the upregulation of OXPHOS mediated by peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and increased levels of ATP whereas the parallel downregulation of the ERK1/2 pathway reduced the glycolytic cascade and lactate levels. Here, MAPK3 is linked to non-small cell lung carcinoma.