ARHGDIA and central nervous system cancer: As results, more than one thirds of human glioma tissues (n = 25, 34.2 %) had ARHGDIA-negative expression, and other 48 cases (65.8 %, 48/73) showed weak expression of ARHGDIA in cytoplasm (Fig. 1B-f ), with mean staining scores 1.396 ± 0.08.