NRG1 and Anxiety: The combined effect of NRG1 heterozygous knockout and chronic social defeat stress (via intermittent access to an aggressive CD1 strain conspecific) during adolescence produced genotype-dependent working memory deficits and elevated basal cytokine levels during adulthood in TM-NRG1 mutant mice relative to controls [86]. TM-NRG1 mutants displayed a genotypic increase in novelty-induced activity, disruption of PPI and social novelty preference, and decreased anxiety relative to wildtypes.