While neither the DISC1 mutation nor neonatal immune challenge were independently associated with any phenotypic effects, transgenic mice expressing a dominant-negative form of DISC1 displayed a pronounced schizophrenia-related phenotype across several cognitive endophenotypes (spontaneous Y-maze alternation [which measures working memory processes], recognition memory, and contextual fear memory) following neonatal immune challenge. The gene discussed is DISC1; the disease is schizophrenia.