Mice containing a point mutation in the SNAP-25 gene display several schizophrenia-associated endophenotypes including hyperactivity and increased behavioural sensitivity to psychostimulants, which are both mediated through DA D2 receptor activation [181, 182]. SNAP-25 mutants were demonstrated to be particularly sensitive to the disruptive effects of variable prenatal stress on social novelty preference [183]. The gene discussed is SNAP25; the disease is schizophrenia.