NRG1 and schizophrenia: In this study, distinct phenotypic effects across schizophrenia-related behavioural measures (social interaction, PPI, and open-field exploration) were observed for both individual environmental variables as well as interactions between these factors and genotype [92]. NRG1 mutants demonstrated impaired social novelty preference, PPI, and a sex-specific (females only) decrease in spatial working memory performance, irrespective of exposure to the stressor.