Reelin is a protein that is involved in brain development and synaptic plasticity; Reelin-mediated signalling pathway dysfunction has been linked with the pathophysiology of schizophrenia [190, 191]. Reeler is an autosomal recessive mutant mouse containing a mutation in the RELN gene, and several studies have examined the phenotypic consequences of interaction between early life adversity and the heterozygous reeler mouse phenotype. The gene discussed is RELN; the disease is schizophrenia.