Even if AMPK negatively regulates cyclooxygenase 2 (COX-2), a proinflammatory enzyme associated with tumourigenesis, and can induce phosphorylation of tumour suppressor p53, resulting in cell cycle arrest, the main molecular mechanism involved in the AMPK-mediated tumour suppression is the negative regulation of PI3K/Akt/mTOR signaling pathway [33]. The gene discussed is PTGS2; the disease is neoplasm.