In addition to TLR2 and TLR4 at least one additional microglial transmembrane LPS receptor CD14 mediates phagocytosis of both bacterial components and Aβ42 peptides, hence expanding roles for microglia and microglial LPS receptors in the pathophysiology of AD (Lee et al., 2008; Halmer et al., 2015; Jiang et al., 2016). The gene discussed is TLR4; the disease is Alzheimer disease.