TLR2 and Alzheimer disease: Of further interest is: (a) that microbial amyloids induce pro-inflammatory interleukin IL-17A and IL-22, triggers for NF-kB activation/signaling and cyclooxygenase 2 activation via direct TLR2 activation (Nishimori et al., 2012); and (b) that increased levels of both IL-17A and IL-22 are associated with age-related inflammatory neurodegenerative diseases such as AD (Zhang et al., 2013; Calsolaro and Edison, 2016; Maldonado et al., 2016; Richards et al., 2016).