Large-scale NotI-microarray analyses of genetic and epigenetic alterations in the genes of chromosome 3 in RCC revealed that leucine-rich repeats containing 3B (LRRC3B) and Von Hippel-Lindau (VHL) genes possess the highest frequency of deletions and/or methylations in renal carcinoma [14, 15]. Here, VHL is linked to renal carcinoma.