LRRC3B and gastric cancer: Previously we reported changes in the LRRC3B gene promoter during the search for genetic and epigenetic alterations in chromosome 3 in epithelial tumors using NotI-microarrays [14, 67, 68]. LRRC3B was identified by Kim et al. [69] as a putative gene suppressor of several tumors that are silenced in gastric cancers by epigenetic mechanisms.