RASSF1 and cancer: Analysis of simultaneous methylation of CpG islands of the LRRC3B, FHIT, АPС, and RASSF1 genes showed that all the samples from cancer patients contained at least one methylated promoter; two promoters were methylated in 33.3%, three promoters were methylated in 27%, and four methylated promoters were detected in 11.1% of the samples (Tables 3 and 4).