VEGFA and age-related macular degeneration: Within the last decade, intravitreal injection (IVI) therapy using anti-VEGF agents (e.g., aflibercept, bevacizumab, and ranibizumab) has emerged as an essential treatment strategy for tackling many forms of ocular neovascularization in AMD, polypoidal choroidal vasculopathy (PCV), and diabetic retinopathy7, 8.