In 2010, a genome-wide association study (GWAS) by Pfeufer et al. detected an intronic SNP (rs6800541) in SCN10A that is independently associated with PR-interval and AF risk (P = 9.7 × 10−82, P = 0.5 × 10−4, respectively)16. The gene discussed is SCN10A; the disease is atrial fibrillation.