CCN1 and acute lymphoblastic leukemia: To explore whether increased Cyr61 in ALL BM could regulate ALL cell survival, 3 primary T-ALL cells and 3 primary B-ALL cells (see Supplementary Table S3: P1-P6) were cultured in BM supernatants from ALL patients newly diagnosed without any treatment (see Supplementary Table S3: P1-P6), and the results showed that the anti-Cyr61 monoclonal antibody 093G9 could decrease the survival of primary ALL cells cultured in BM supernatants (Fig. 2a, T-ALL p = 0.0349, *p < 0.05, B-ALL p = 0.0151, *p < 0.05, Student’s t-test).