Our results indicated that treatment with PDTC blocked Cyr61’s up-regulation of Bcl-2 expression in ALL cells (Fig. 5c, Jurkat p = 0.0412, *p < 0.05, Nalm-6 p = 0.0427, *p < 0.05, ANOVA with Student-Newman-Keuls tests). Here, CCN1 is linked to acute lymphoblastic leukemia.