Because early studies have shown that Cyr61 induces NF-κB activation via the PI3K/AKT pathway in breast cancer cells and fibroblast-like synoviocytes56, 57, 58, 59, we suggest that Cyr61-induced ALL cell survival depends on the AKT/NF-κB signaling pathway. The gene discussed is AKT1; the disease is acute lymphoblastic leukemia.