CCN1 and acute myeloid leukemia: Numerous studies have demonstrated that Cyr61 is an important ECM protein that plays a key role in the pathogenesis of tumors26, 27, 28, 29, 30, 31; recent studies have shown that Cyr61 is involved in stroma-induced chemo-resistance in acute myeloid leukemia (AML)24 and that inhibiting Cyr61 could block AML cell growth24, 25.