CXCL16 and breast neoplasm: In summary, the findings from our study indicate that myeloid cells are recruited preferentially to TN breast tumours where they become skewed to immunosuppressive myeloid cells (CD163+S100A9+), activate CAFs and induce expression of CXCL16 in CAFs that in turn can recruit more myeloid cells and fibroblasts, but also T cells (Fig. 7b).