PTGS2 and adenomyosis: Since TXA2, PGH2, and PGI2 have been reported to be potent inducers of uterine contractility [73] and uterine contractility is documented to be  correlated with the severity of dysmenorrhea in adenomyosis [44], the suppression of platelet activation and the resultant COX-2 down-regulation may suppress hyperinnervation and uterine hyperactivity, thus responsible for improved generalized hyperalgesia and reduced  plasma CORT levels.