TGFBI deficiency predisposes mice to spontaneous tumor development (lymphoma, lung adenocarcinoma) and TGFBI−/− mice have reduced body size, bone mass, bone size, and decreased periosteal bone formation, suggesting that TGFBI functions as a tumor suppressor and plays an important role in regulating bone homeostasis in vivo [74, 75]. The gene discussed is TGFBI; the disease is lung adenocarcinoma.