How claudin-4 is inhibiting apoptosis in ovarian tumors is not known, however, we have previously shown interfering with claudin-4 in normal mammary epithelial cells with DFYNP disrupts claudin-4 localization and induces death by interacting with occludin and components of the death inducing signaling complex (DISC) to activate the extrinsic apoptotic pathway [3]. This evidence concerns the gene OCLN and ovarian neoplasm.