In our study, we did find a significant increase in renin, Ang II and ACE, which was the same for AT1 receptor, AT2 receptor and MR expression in the pulmonary and right ventricular tissue, acompanied with thickening of the vascular wall and altering of hemodynamic parameters indicating PAH and RV dysfunction. This evidence concerns the gene AGTR2 and pulmonary arterial hypertension.