Interestingly, SNPs that showed LD with the rs1863918 (r2 = 0.83–0.91) cluster at the 3ʹ-UTR (rs6870503) and intron (rs1106858, rs17666172, and rs11746026) of ZNF354C. Our study suggests that ZNF354C is highly expressed in the hippocampus and might be implicated in the pathology of depression. Here, ZNF354C is linked to major depressive disorder.