The SNP rs1863918 in strong linkage disequilibrium with SNPs located around the Zinc finger 354C (ZNF354C) gene on chromosome 5 showed a significant association when the results of GWAS and replication were combined (odds ratio = 2.55, P = 7.89×10−8 in the allele frequency model), suggesting that the rs1863918 T allele was associated with IFN-induced depression. This evidence concerns the gene IFNA1 and major depressive disorder.