Based on the mouse peritoneal xenograft model and human GEO datasets, the present study provides evidence that NF-κB mediated CCL20 is a dominant chemokine in the progression of ovarian cancer and is further potentiated even in CXCR2-driven ovarian progression which utilizes CXCL1-3 and 5–8 as CXCR2 ligands. The gene discussed is CXCL1; the disease is ovarian cancer.