These chemokine signatures in EOC cells appear to shift during the peritoneal spreading, leading to dominant expression of CCL20 and CXCR4 through cell-cell communication in the tumor microenvironment as follows: CCL2-CCR2 and CXCL1-3/8-CXCR2 axes via interaction with OSE, and CXCL12-CXCR4 and CXCL12-CXCR7 axes via interaction with NOS. This evidence concerns the gene CXCR4 and neoplasm.