Concurrently, the analyzed results showed that there is shift of dominant chemokines from CXCL1-3 and 8 (CXCR2 ligands) to CCL20 between pre-spreading (in vitro) and post-spreading (in vivo) in ovarian cancer (Fig 6D), as demonstrated in our mouse peritoneal spreading model. The gene discussed is CXCR2; the disease is ovarian cancer.