For example, the function of the basic leucine zipper transcription factor CCAAT/enhancer binding protein-α (C/EBPα), one of the crucial transcription factors for myeloid cell development, is frequently abrogated in AML by mutations but also through epigenetic modification through hypermethylation of the CEBPA promoter [48–52]. This evidence concerns the gene CEBPA and acute myeloid leukemia.