All the other 10 genome-wide significant SNPs were in strong linkage disequilibrium (LD) with rs9409565 (LD r2>0.8, S3 Table, Fig 3) and some of them were located within the gene HIATL1. The observed interaction for rs9409565 was similar in men and women and by cancer site (colon vs rectum) (Fig 4A and 4B, S4 Table). This evidence concerns the gene SLC71A2 and cancer.