Furthermore, we observed that HIATL1 showed significant differential expression across various levels of lifetime alcohol consumption in the colon tumor tissues (n = 28, ANOVA test P = 0.03, S3 Fig) and also had differential gene expression across levels of alcohol consumption at reference time (the year before enrollment) in the normal colon tissues (n = 33) at P = 0.06 from ANOVA test (S4 Fig). Here, SLC71A2 is linked to colonic neoplasm.