IFNA1 and chronic hepatitis C virus infection: Considering a virtual cohort of 1,000 patients and assuming the same prevalence of fibrosis F≥3 (30.5%) as that observed in our cohort of patients with chronic hepatitis C, and using the cut-off value of 6.8 kPa maximizing the benefit of IFN-free regimen, we would obtain 20 false negative and 408 false positive results.