Considering a virtual cohort of 1,000 patients, and assuming the same prevalence of fibrosis F≥2 (53.2%) as that observed in our cohort of patients with chronic hepatitis C, and using the cut-off value of 4.5 kPa maximizing the benefit of IFN-free regimen, we would obtain 6 false negative and 413 false positive results. Here, IFNA1 is linked to chronic hepatitis C virus infection.