CD14 and Alzheimer disease: As CD14 specifically binds fibrillar Aβ42 (Fassbender et al., 2004), the difference between the two AD models could be explained by the higher ratio of Aβ42/Aβ40 in TgAPP/PS1 compared to TgAPP/PS1dE9 (ratio Aβ42/Aβ40 insoluble ≥ 15 for TgAPP/PS1 and ≥ 6 for TgAPP/PS1dE9, data not shown).