Hazard ratio for breast cancer-specific mortality was 0.44 (95 % CI 0.27–0.71, p = 0.001) for ER+/PgR+ patients and 0.65 (95 % CI 0.35–1.21, p = 0.17) for ER+/PgR− patients. The gene discussed is ESR1; the disease is breast carcinoma.