Other lysine demethylases such as UTX/KDM6A, JMJD3/KDM6B, and JMJD2C/KDM4C have important roles in the differentiation of cardiac cells from their regulating progenitors, but their role in cardiac hypertrophy is elusive [21, 22]. The gene discussed is KDM4C; the disease is cardiac hypertrophy.