FASN and cancer: The toxicological significance of the inhibitory effect of TCS on human fatty acid synthase (Liu et al. 2002) is not well understood though its anti-proliferative effect has been reported in some cancer cells (Honkisz et al. 2012), however administration of TCS orally to rats, dogs and baboons was reported to produce minimum toxicity in these animals (Bhargava and Leonard 1996).