Although several clinical studies have shown that Bcl-2 expression is associated with neck lymph node metastasis and poor prognosis in oral cancer (Camisasca et al. 2009; Mallick et al. 2009; Popovic et al. 2007), the functional roles of Bcl-2 in OTSCC and whether it is involved in the resistance of OTSCC to chemotherapy are not well understood. This evidence concerns the gene BCL2 and lip and oral cavity carcinoma.