TARDBP and amyotrophic lateral sclerosis: Using an image-based screen based on TDP-43 aggregation in neurons generated from ALS hiPSCs, they discovered that known small molecule inhibitors of the Na+/K+ ATPase, GSK3 and CDK could ameliorate this phenotype, providing supporting not only for prior studies that have implicated these proteins as potential ALS therapeutic targets but also the use of patient-derived iPSCs for drug discovery [4].