TNF and type 1 diabetes mellitus: According to an in vivo study on STZ-induced T1DM C57BL/6J mice, curcumin at a dose of 1500 mg/kg/day for two weeks ameliorated skeletal muscle atrophy by inhibiting NF-κB activation, inflammatory cytokine (TNF-α and IL-1β) concentrations, oxidative stress, and protein ubiquitination [123].