IL6 and rheumatoid arthritis: In LPS-stimulated macrophages, the secretion of IL-6 (found at elevated levels in patients with RA) was significantly reduced (by at least 25%) upon incubation with polyphenol-rich extracts of rooibos tea, black pepper, ginger, allspice, caraway, bay leaves, cinnamon, licorice, paprika, clove, nutmeg, and apples [206].