TNF and type 1 diabetes mellitus: In the liver and spleen of STZ-induced male Long-Evans rats (type 1 diabetic animal models), resveratrol treatment (0.1 or 1.0 mg/kg/day) for 7 days significantly reduced oxidative stress (including superoxide anion content, protein carbonyl level, and manganese-superoxide dismutase expression) in hepatic and splenic tissues, and it reduced hepatic inflammation (NF-κB and IL-1β) and decreased the TNF-α and IL-6 levels in diabetic spleen [104].