A similar study on GSPE using human adipocytes (SGBS) and macrophage-like (THP-1) cells found reduced cytokine (IL-6 and MCP-1) gene expression after an inflammatory stimulus and enhanced the production of the anti-inflammatory adipokines adiponectin (APM1) and LEP, which may prevent the low-grade inflammation of T2DM [112]. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.