TP53 and cancer: With regard to the growing literature on the involvement of aggregated forms of p53 in different cancer cells lines and tumor tissues (Levy et al., 2011; Ano Bom et al., 2012; Lasagna-Reeves et al., 2013; Silva et al., 2014; Yang-Hartwich et al., 2015) and given that p53 is marginally stable inside the cell and that aggregation depends on protein concentration, it is reasonable to argue that misfolded and aggregated forms of p53 might also occur in other unrelated diseases.