It was determined by both, elasticity analysis and kinetic modeling (experimental strategies of metabolic control analysis and bottom-up Systems Biology, respectively), that the main controlling steps of cancer glycolysis are the glucose transporter (GLUT), hexokinase (HK), hexose phosphate isomerase (HPI), and glycogen degradation, regardless the environmental conditions to which the cells were exposed (normoxia/normoglycemia, hypoxia/hyperglycemia, and normoxia/hypoglycemia; Marín-Hernández et al., 2006, 2011, 2014). Here, HK1 is linked to cancer.