GAPDH and cancer: However, non-flux-controlling glycolytic steps such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), pyruvate kinase (PYK), and lactate dehydrogenase (LDH) have been also proposed as suitable targets for inhibition of cancer glycolysis (Ganapathy-Kanniappan et al., 2012; Ganapathy-Kanniappan and Geschwind, 2013; Daniele et al., 2015).