However, there are experimental evidences indicating that oxamate and iodoacetate, presumed specific inhibitors of LDH and GAPDH, i.e., two non-controlling glycolytic enzymes, do affect the glycolytic flux of cancer, and non-cancer cells (Goldberg et al., 1965; Elwood, 1968; McKee et al., 1968; Coe and Strunk, 1970; Chatham et al., 1988; Moreno-Sánchez et al., 2016). This evidence concerns the gene HK1 and cancer.