PHKA2 and sarcoma: These analyses strongly suggested that the increase in Fru1,6BP and DHAP levels reported in AS-30D, Ehrlich ascites, sarcoma 37 ascites and HeLa cells treated with oxamate (Goldberg et al., 1965; Elwood, 1968; Coe and Strunk, 1970; Moreno-Sánchez et al., 2016), was a consequence of ENO and PYK inhibition rather than of LDH inhibition, contrary to the most common interpretation.