MOG and obesity due to melanocortin 4 receptor deficiency: In vitro, Peroxisome Proliferator-Activated Receptor gamma (PPAR-γ), a regulator of adipocyte differentiation implicated in obesity [60], is strongly upregulated following demyelination mediated by antibodies directed against the Myelin Oligodendrocyte Glycoprotein (MOG) in the presence of complement [61].