GRK2 and colitis: We isolated neutrophils from bone marrow of mice with DSS-induced acute colitis and found that expression of CXCR2 was significantly increased in inflamed colon of DSS-induced colitis mice after blockade of PLD2 and that GRK2 expression was markedly decreased after PLD2 inhibition compared with WT controls (Figures 7(c) and 7(d)).