However, we also found that PLD2 expression was increased in peripheral blood and inflamed mucosa of IBD patients, the mechanisms whereby increased infiltration of neutrophils may be also attributed to other molecules (e.g., TRPC6, IL-18, IL-8, Lewis X, and MAPK p38) at different stages of intestinal mucosal inflammation [51–54]. This evidence concerns the gene PLD2 and inflammatory bowel disease.