Ischemia reperfusion (IR) induced the expression of NLRP3 in mice renal tissues, and NLRP3 gene knockout mouse model can remarkably ameliorate IR-induced AKI including acute tubule necrosis, expression of IL-18 and IL-1β, alleviate impaired function and reduce mortality8, 25. This evidence concerns the gene IL1B and acute kidney tubular necrosis.