CD4 and infection: I.v. injection of 3BNC117, one of the most potent anti-CD4 binding site neutralizing antibody reported to date, with a plasma half-live of 3.3 days when injected at 5 mg/kg also prevents the acquisition of SHIVAD8-EO infection following rectal challenge55 and in infected humans, where the half-life was 9 days, a 30 mg/kg injection reduced the viral load by 0.8 to 2.5 log1037.