CXCL16 is highly expressed in the brain during pathological conditions like multiple sclerosis, glioma, schwannomas and meningiomas23, 25, 26, 27, 28, 29, 30; moreover, CXCL16/CXCR6 signaling has been recently described to play a crucial role in counteracting brain glutamate excitotoxic damage upon cerebral ischemia. This evidence concerns the gene CXCL16 and Cerebral ischemia.