IFNG and primary biliary cholangitis: Indeed our data is consistent with recent data in another murine model that mice with a deletion of the IFN-γ 3’ untranslated region adenylate-uridylate–rich element have prolong and chronic expression of IFN-γ and develop a primary biliary cholangiopathy similar to PBC, which likewise proposes a key role of IFN-γ in disease initiation32, 33.