Thus, overexpression of GATA4 enhances hepatic expression of Abcg5 and Abcg8, and cholesterol excretion to the bile in L-Bmal1−/−Apoe−/− and Bmal1fl/flApoe−/− mice, while reducing MTP expression and atherosclerosis. The gene discussed is ABCG5; the disease is atherosclerosis.