Of note, we could not find significant changes in the expression of the nuclear coactivator PPARγ coactivator-1α (PGC1α), a master regulator of mitochondrial biogenesis previously implicated in cancer metastasis11, 12, between metastatic melanoma vs primary tumours (BH-P value=0.37). The gene discussed is PPARGC1A; the disease is metastatic melanoma.