SRI and cancer: In contrast an RNAi knockdown of either TRAP1 and/or the TRAP1 interactor protein Sorcin was found to sensitize colon cancer cells to cancer agents that induce apoptosis, suggesting that agents targeting TRAP1/Sorcin (e.g., Shepherdin, Gamitrinibs, see below) may constitute a therapeutic strategy for colorectal tumours [114].