G6PD and G6PD deficiency: In patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency PQ generally induces RBC oxidative damage that eventually results in hemolytic anemia which may be severe.33, 34 Such toxicological concerns have led to restrictions in the use of this drug since the incidence of G6PD genetic anomaly is particularly high in areas where malaria is endemic,35 a situation that calls for new methods addressed to the targeted delivery of PQ active species to pRBCs.