Another study showed that ICG-001, a small molecule which inhibits WNT/β-catenin signaling via interaction between β-catenin and CREB-binding protein (CBP), an intrinsic histone acetyltransferase to activate gene transcription, increased alveolarization and decreased vascular remodeling to develop pulmonary hypertension [104]. Here, CREBBP is linked to pulmonary arterial hypertension.