In a similar fashion, aberrant activation of Stat3 induces constitutive expression of suppressor of cytokine signaling-3 (SOCS3), which attenuates the effects of several cytokines, including IFN-γ and IFN-α and, consequently, protects the malignant T cells from cytokine-mediated anti-tumor responses [113]. The gene discussed is STAT3; the disease is neoplasm.