IL-22 has been reported to correlate with the expression of CCL20 in CTCL lesions, and siRNA-mediated knockdown of IL-22 receptor alpha (IL-22RA) in malignant CTCL cells inhibited the expression of CCL20, providing a possible link between IL-22, the CCR6-CLL20 axis, and malignant dissemination [55, 56]. The gene discussed is IL22; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.