The hostile takeover is exemplified by the tumor cell-mediated induction of (i) malignant growth factors such as IL-4, IL-13, and IL-15 from non-malignant cells, (ii) M2-like TAMs, mast cells, and immature dendritic cells that provide growth and survival signals to the malignant T cells, and (iii) angiogenesis via stimulation of fibroblasts, innate immune cells and endothelial cells. The gene discussed is IL15; the disease is neoplasm.