Dysregulation of the Jak/Stat pathway emerges as a central event in the development of malignant inflammation in CTCL and, indeed, evidence from various other cancers also points towards a central role for certain Stat proteins (e.g., Stat3) in sustaining chronic inflammation while antagonizing anti-tumor responses [153]. Here, STAT3 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.